Description

4-ANPP-¹³C₆ (CRM) is a certified reference material intended for use as an internal standard for the quantification of 4-ANPP by GC- or LC-MS. 4-ANPP is categorized as a piperidinamine. It is an intermediate in the synthesis of fentanyl from N-phenethyl-4-piperidone .¹ As such, 4-ANPP has been used as a precursor for the manufacture of fentanyl and related opioids. 4-ANPP is also an impurity found in fentanyl preparations. It is a known metabolite of acetyl fentanyl , butyryl fentanyl , furanyl fentanyl , acrylfentanyl , and fentanyl.^2,3,4,5 4-ANPP-¹³C₆ is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.

4-ANPP, also known as 4-anilino-N-phenethylpiperidine (4-ANPP), 4-aminophenyl-1-phenethylpiperidine, or despropionyl fentanyl,^[3] is a direct precursor to fentanyl and acetylfentanyl. It is commonly found as a contaminant in samples of drugs containing fentanyl, which may include samples represented by the supplier as heroin or other opioids.It is not psychoactive and is present only as a result of improper chemical purification. 4-Anilino-N-phenethylpiperidine (4-ANPP)

4-ANPP is useful in the synthesis of pharmaceuticals, primarily fentanyl and related analogs. Paul Janssen (founder of Janssen Pharmaceutica) first synthesized fentanyl in 1960 using a similar method, with Benzylfentanyl as an intermediate.The following synthesis, developed by an individual under the pseudonym of Siegfried, involves the reductive amination of N–phenethyl-4-piperidinone (NPP) with aniline to make to 4-ANPP. This product is reacted with propionyl chloride or acetyl chloride to form either fentanyl or acetylfentanyl.

Synonyms