Description

Description of N-Phenethyl-4-piperidinone (NPP) CAS 39742-60-4

N-Phenethyl-4-piperidinone (NPP) (CAS 39742-60-4) is an organic heterocyclic compound with the molecular formula C₁₃H₁₇NO and a molecular weight of 203.28 g/mol. Also known by its IUPAC name 1-(2-Phenylethyl)piperidin-4-one, NPP is a piperidone derivative primarily used as a chemical research material and as a specialized intermediate in pharmaceutical and fine chemical development. Its structure contains both a piperidone ring and a phenethyl substituent, making it a valuable building block for synthetic chemistry applications.

NPP has attracted significant regulatory attention because it is recognized internationally as a key precursor chemical associated with the synthesis of fentanyl and certain fentanyl analogs. As a result, its manufacture, distribution, import, export, and handling are subject to strict legal controls in many countries. In the United States, NPP has been designated as a DEA List I Chemical, while numerous other jurisdictions have adopted comparable precursor-control measures to reduce the risk of diversion into unauthorized manufacturing. Companies and laboratories working with NPP are therefore expected to comply with all applicable licensing, recordkeeping, reporting, and regulatory requirements.

Under standard conditions, NPP is handled exclusively in professional laboratory and industrial environments. The compound should be stored in tightly sealed containers in a cool, dry, and well-ventilated area, away from incompatible materials. Personnel handling NPP should follow established laboratory safety protocols and consult the relevant Safety Data Sheet (SDS) before use.

Beyond its regulatory significance, NPP remains an important compound in legitimate scientific research involving heterocyclic chemistry, medicinal chemistry, analytical method development, and reference standard preparation. Academic institutions, research laboratories, and qualified industrial organizations may utilize NPP in controlled research settings where permitted by applicable laws.

Chemical Information

• Product Name: N-Phenethyl-4-piperidinone (NPP)
• IUPAC Name: 1-(2-Phenylethyl)piperidin-4-one
• CAS Number: 39742-60-4
• Molecular Formula: C₁₃H₁₇NO
• Molecular Weight: 203.28 g/mol
• Synonym: NPP

N-Phenethyl-4-piperidinone is intended for legitimate research, analytical, and industrial applications only. Purchasers should ensure that acquisition, possession, transportation, and use comply with all local, national, and international regulations governing controlled precursor chemicals.