Description of Procaine powder cas 59-46-1

Procaine powder can be used as a raw material, chemical material in the laboratory. These physical properties help characterize its purity and solid-state structure. The electrical charge is neutral, so it does not have the advantages of electrostatic force and repulsive force. This limits its potential in technological applications. It is a chiral compound with both left-handed and right-handed properties. This optical activity is due to the chiral center in its molecule. The rotation of left rotation is -14.3 °, and the rotation of right rotation is+13.9 °. It has low toxicity. When used at the correct dosage, it is usually a safe anesthetic. However, excessive or misuse can lead to toxic reactions, including death. Overall, as an anesthetic drug, the study of its physical properties is crucial for its application and production, and these characteristics will also play an important role in the fields of technology and medicine.

Procaine acts primarily by inhibiting the inward flow of sodium ions from voltage-gated sodium channels in the cell membranes of neurons in peripheral nerves. When the inward flow of sodium ions is interrupted, action potentials cannot occur and signaling is thus inhibited. The receptor site is thought to be located in the cytoplasmic (inner) portion of the sodium channel.Procaine is also capable of binding to or antagonizing the function of N-methyl-D-aspartate (NMDA) receptors as well as nicotinic-type acetylcholine receptors and 5-hydroxytryptamine receptor-ion channel complexes.Procaine is an inhibitor of calcium- and caffeine-induced calcium release in various types of muscle preparations.0.5 mMProcaine blocks sarcoplasmic reticulum Ca in individual lipid bilayersProcaine can be used as a DNA demethylating agent with inhibitory effects on human cancer cell growth.
0.5 mMProcaine was able to reduce 5-methylcytosine DNA by 40% in the MCF-7 breast cancer cell line.Procaine is also able to bind to CpG-enriched DNA and demethylate densely hypermethylated CpG sequences, resulting in the restoration of gene expression of genes that have been epigenetically silenced.Procaine treatment (0.5 mM) increased cellular in M-phase mitotic index.Procaine treatment (1 mM) reduced cell proliferation by ~40%.Procaine affects the shape and deformability of erythrocytes.45 mMProcaine almost completely prevents the discoidal-spiny erythrocyte transition associated with ATP depletion. Similar concentrations of Procaine normalized ATP-depleted cell adhesion and filtration, but had no effect on cell volume, osmotic fragility, or monovalent cation composition.